Manfred Kössl

Univ.-Professor, Head of AK Neurobiology and Biological Sensors


Research projects

1. Complex Sound Processing in the Gerbil Midbrain and Auditory Cortex

By presenting tone complexes to the ear that will produce mechanical distortions in the cochlea, we study the neuronal computation of cochlea-generated otoacoustic emissions. One of our main aims is to investigate the role of cochlear two-tone distortions for pitch-perception.
In addition we investigate neuronal computation of auditory streaming by presenting melody-like sequences of the tone pulses and analysing neuronal preferences to specific parts of the auditory stream.

Methods: Simultaneous OAE-recording and extracellular neuronal recordings, acoustic masking techniques.

Support: DFG Ko987/9-1


2. Development of Time Computation in the Auditory Cortex of Bats

The postnatal development of time-sensitive neuronal circuits is investigated in the secondary auditory cortex of the bats Pteronotus parnelii and Carollia perspicillata. Specifically, we study the physiological and neuroanatomical properties of delay-sensitive neurons that use the delay between echolocation call and echo to derive the target distance during echolocation. The studies on P. parnelli are performed in Cuba. Here we have access to young mustached bats that are reared in maternity colonies in hot caves. The project is a collaboration between the Univ. of Frankfurt, the Univ. of Potsdam, and the Univ. of Havana.

Methods: Extracellular recording techniques, immuno-histochemistry, acoustic deprivation techniques

Support: DFG Ko987/10-1


Boa and Pteronotus parnellii


3. Evolution of Auditory Systems in Mammals and Insects

Animals adapted to different acoustic environment are investigated in terms of their ear mechanics.
In mammals, the focus of the project is on how efferent innervation to the outer hair cells influences the cochlear amplifier. As model species we use humans, gerbils and two bat species, Carollia perspicillata and Pteronotus parnellii. The mustached bat, P. parnellii, has a dedicated constant-frequency (CF) echolocation system and an auditory fovea in the inner ear that produces extreme frequency resolution and high sensitivity to CF-echoes.
In insects, we focus on the role of putative motor proteins for sensory transduction in the scolopidia of tym­panal organs in bush crickets, locusts, and moths. In addition we study the action of insecticides on the sensory neurons in insects.

Methods: Noninvasive measurement of Otoacoustic Emissions (OAEs), electrophysiology, laser-interferometry, immuno-histochemistry, in-situ hybridisation, gene-sequencing, modelling.

Support: DFG Ko987/8-2, Jürgen Manchot Foundation, Evangelisches Studienwerk


Basalturn of Pteronotus parnellii (Bild: M. Vater)



2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001


geändert am 14. Oktober 2013  E-Mail: Webmaster AK


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Druckversion: 14. Oktober 2013, 12:29